Drozdenko was born in the village of Akzhar, Bayzak District, Jambyl Region, Kazakh Soviet Socialist Republic, USSR.

On 5 May 2012, the President of Russian Federation introduced Alexander Drozdenko for consideration by the Legislative Assembly of Leningrad Oblast as a nominee for the position of Governor.

Since 2014, Leningrad Region has been consistently included in the top ten constituent entities of the Russian Federation by volume of investment growth in fixed capital.

[7] Based on the results for 2017, Leningrad Region took 12th place in the National Rating for Investment Attractiveness[8] established by the Agency for Strategic Initiatives.

He supported the initiative group to shut down the Krasny Bor hazardous waste landfill site operated by Saint Petersburg within the region's territory.

For compensatory accelerated development of infrastructure in new-build areas, the "Public Amenities in Exchange for Taxes" program was implemented.