From 1853 until 1858 he studied medicine at the University of Moscow, and furthered his education in Germany, Switzerland, England and France.
At Jean Martin Charcot's laboratory in Paris he made important pathological correlations in the study of amyotrophic lateral sclerosis (ALS).
In 1869 he returned to Moscow, where he worked at the Novo-Ekaterininskii Hospital, and gave classes in neurologic and psychiatric diseases.
He provided a comprehensive description of progressive familial spastic diplegia, and made contributions in the neuropathological study of nuclear ophthalmoplegia and asthenic bulbar paralysis.
Among his students and assistants were Sergei Korsakoff (1853-1900), Grigory Ivanovich Rossolimo (1860-1928), Liverij Osipovich Darkshevich (1858-1925), Vladimir Karlovich Roth (1848-1916), Lazar Salomonovich Minor (1855-1942) and Edward Flatau (1869-1932).