Fra' Alessandro Ponziano Borgia (October 30, 1783, Velletri, Papal States – January 13, 1872, Rome) was the leader of the Sovereign Military Order of Malta as Lieutenant of the Grand Master from 1865 to 1872.

[1] His mother was Countess Alcmena Baglioni-Malatesta, descended from the Baglioni family which formerly ruled the city of Perugia.

[4] In 1818 he took up residence at the Order's headquarters (called the "Convent") in Catania where he served as Procurator of the Langue of Italy.

[4] Under the Lieutenant Carlo Candida he was promoted to the rank of Venerable Bailiff Knight Grand Cross.

He was succeeded as Lieutenant of the Grand Master by Fra' Giovanni Battista Ceschi a Santa Croce.