According to the Nigel Williams autobiography "Had ik maar een vak geleerd" ("If Only I'd Learned a Proper Trade"), Alex was already an established comedian in Belgium since at least the 1999–2000 season.

Undisputedly however, he attained nationwide fame when he became the first Belgian to win the prestigious Dutch Leids Cabaret Festival in February 2003.

After filling up the Antwerp Sportpaleis 5 times over throughout 2011 with his best-of show "Larger than Life" supported by Steve Hughes.

On 16 September 2012 Agnew announced his "indefinite" retirement from stand-up comedy on his official website and Belgian public television.

Right now he's writing material for his latest show "Be Careful What You Wish For" Agnew's wife runs a popular comedy club, The Joker, in Antwerp.