In 2008, his senior year, Meyer had an 8–0 win–loss record, a 0.95 earned run average (ERA), and 108 strikeouts in 51 innings pitched.

Despite being reportedly offered as much as $2.2 million as a signing bonus, Meyer chose not to sign with the Red Sox so that he could follow through on his commitment to attend the University of Kentucky to play college baseball for the Kentucky Wildcats baseball team.

[5] He pitched for the Hagerstown Suns of the Class A South Atlantic League in 2012, and was named to appear in the All-Star Futures Game at midseason.

[11] Pitching for the Rochester Red Wings of the Class AAA International League in 2014, Meyer was named to the All-Star Futures Game.

[16] The Twins promoted Meyer to the major leagues on April 25,[17] but optioned him back to Rochester on May 3, after making two appearances for Minnesota.

[18] On August 1, 2016, the Twins traded Meyer and Ricky Nolasco plus cash for Angels pitchers Hector Santiago and Alan Busenitz.

On September 11, 2017, Angels general manager Billy Eppler announced that Meyer would undergo surgery to repair a torn labrum in his right shoulder.

[22] Meyer retired from professional baseball on June 25, 2019, citing multiple surgeries and countless hours of rehab marking the end of the road.