He is known for founding the online community Wrong Planet, working on FX's television series The Bridge, and acting on The Good Doctor.

[6] Alex Plank's story regarding the founding of Wrong Planet is covered in the special education curriculum of many universities in the United States.

[14] Plank introduced a variety of autistic tendencies into Kruger's character of Sonya Cross, including stimming, awkwardness around eye contact, and a flat affect.

[15] In 2019, Plank guest starred in season 2 of The Good Doctor as Javier Maldonado, the roommate of Lana Moore, a patient who needs to undergo brain surgery.

[25] According to People Magazine, Plank spoke at a conference in San Diego during which he was also involved in the first "all-autism" wedding where he served as DJ and best man.

[28] A front-page article from The New York Times, entitled "Navigating Love and Autism", written by Amy Harmon, was published in December 2011 about the romantic relationship between his two autistic co-hosts Jack Robison and Kirsten Lindsmith.

When the film was in post-production it was covered by publications in both France and the United States, including L'Express and Vivre FM, a radio station in Paris; a trailer was released in July 2012.

[30] Along with French activist David Heurtevent, Plank founded Autism Rights Watch, an NGO for which he serves as president.