She was registered at Liverpool in 1801 and proceeded to make six voyages as a slave ship in the triangular trade in enslaved people.

[2] 1st voyage transporting enslaved people (1799–1800): Captain Threlfall sailed from Liverpool on 29 October 1799.

[2] 2nd voyage transporting enslaved people (1801–1802): Captain Ainsworth sailed from Liverpool on 5 September 1801.

[5] 3rd voyage transporting enslaved people (1802–1803): Captain Ainsworth sailed from Liverpool on 18 September 1802.

[4] Alexander acquired captives on the Windward Coast, in the area between Rio Nuñez and the Assini River.

[8] 6th voyage transporting enslaved people (1807–1808): Captain Ward sailed from Liverpool in February 1807.

As she left, on 12 February another vessel ran afoul of her in the Mersey, causing some damage, carrying away all of her upper work on the starboard side of her quarterdeck.

On 25 November a French privateer captured Lucy, an American vessel sailing from Curacoa to Philadelphia.

The Act took effect on 1 May 1807, so Alexander's last voyage was still legal as she had received clearance to sail outward bound in February.