Alexander Francis Macdonald (1818 – April 12, 1913) was a politician and railway contractor.

The son of Alexander Macdonald, he was educated in Cornwall and at St Raphael's College.

Macdonald was president of the Canada Cotton Company.

His brothers, John Sandfield Macdonald and Donald Alexander Macdonald, were also Members of Parliament.

[1] On Mr. Macdonald being unseated on petition, 7 September 1874: