[3] Swedish by birth, Michel Melki represented them at youth level before also acquiring Lebanese nationality through his grandfather on his father's side.

After following his father's tracks playing at Syrianska for six years, Michel Melki moved to AFC Eskilstuna in 2017, helping them gain promotion back to the Allsvenskan the following season.

[citation needed] Exactly two years after his debut in the Swedish championship, on 20 June 2013 Michel seriously damaged the cruciate ligament of his left knee during a home match against Malmö FF.

[citation needed] Having recovered from the injury, in July 2015 Michel broke the same cruciate ligament damaged two years earlier forcing him to finish the season in advance.

[12][13][14] On 23 January 2019, during the winter transfer window, Alkass Sports Channels officially announced the signing of Michel Melki to Qatar Stars League side Al-Khor until the end of the season.

[21] Michel Melki finished runner-up with Al-Khor in the 2020–21 Qatar Stars Cup, featuring in the final against eventual winners Al-Rayyan.

[29] On 8 August 2022, Michel Melki returned to his former club in Sweden AFC Eskilstuna, reuniting with his brother Felix; he signed a contract until the end of the 2022 Superettan season.

[36] On his 27th birthday, on 14 November 2019, Michel Melki played the whole 90 minutes in a 2022 FIFA World Cup qualifier match against South Korea.

[37] Lebanon held on to a 0–0 draw, with Michel Melki neutralizing Tottenham Hotspur forward Son Heung-min;[38] he was widely regarded as the Man of the Match by Lebanese fans.