He also serves as the Dean of Computer Science at the University of the People on the pro bono basis.

Professor Tuzhilin is known for his work on personalization, recommender systems, machine learning and AI, where he has made several contributions, including being instrumental in developing the area of Context-Aware Recommender Systems (CARS), proposing novel methods of providing unexpected and cross-domain recommendations based on the principles of deep-learning, developing novel approaches to customer segmentation, and discovery of unexpected patterns in data.

[1][2] Tuzhilin joined the faculty at the New York University Stern School of Business in 1989 as an Assistant Professor of Information Systems.

[3] Tuzhilin researches data mining in databases, personalization, recommender systems, and customer relationship management.

[2] In 2006, Tuzhilin was hired by Google and given access to its monitoring systems to do a study on click fraud.