[13] In 2005, after two years at Parsons, Wang decided to pursue the launch of his own fashion label, which debuted with a predominantly knitwear collection.

In Fall 2007, Wang presented a complete women's ready-to-wear collection on the New York catwalk for the first time, to critical acclaim.

[18] Some have noted that the brand has helped to rejuvenate an otherwise dissolving area into fashion's Lower Manhattan epicenter.

[19] On November 30, 2012, Wang was named creative director at Balenciaga, after Nicolas Ghesquière's departure, to oversee the women's and men's ready-to-wear and accessories lines.

[29] In February 2012, a lawsuit was filed against Wang, claiming that his company violated New York State labor laws, and that employees were mistreated.

[34] Fashion industry whistleblower account Diet Prada and modeling industry watchdog account Shit Model Management published posts on Instagram on December 29, 2020, compiling accusations made on social media (TikTok, Twitter and Instagram) by people who said Wang sexually assaulted them.

[35][36] Social media scrutiny ensued when male model Owen Mooney came forward, describing a 2017 incident where he was groped by Wang in a packed New York City nightclub, which was later reposted by Shit Model Management, leading others to come forward with similar stories.

The posts amplified previous allegations from others such as New York-based DJ Nick Ward, who publicly accused Wang of groping him in a nightclub in 2017.

There were also repeat allegations of victims, including several trans women, being groped or having their bodies or genitals exposed by Wang.

[37][38][39] On December 31, 2020, Wang's representatives released a statement to various media outlets, with the designer denying all accusations of sexual assault and that he intended to "hold accountable whoever is responsible for originating these claims and viciously spreading them online.

"[40][41] On January 1, 2021, The Guardian published other alleged accounts of sexual assault incidents from others, including transgender model and actor Gia Garison.

[42] On January 4, 2021, Wang issued an updated statement thanking those who had stood by him, while also assuring that he would "remain honest and transparent" throughout the investigation into the claims.