He joined the far-left and was repeatedly reelected during the entire reign of Louis Philippe: June 21, 1834; November 4, 1837; March 2, 1839; July 9, 1842; and August 1, 1846.
He pestered the established powers with questions and critiques, most of all working toward a reduction in taxes on salt and letters and the abolition of required stamps for journals.
Glais-Bizoin said, "Bonapartist ideas are one of the open wounds of our time; they represent that which is most fatal to the emancipation of peoples, most contrary to the independence of the human spirit."
After having associated himself with those demanding the indictment of François Guizot, the last prime minister in the July Monarchy, he rallied to the newly established French Second Republic.
Toward the end of the French Second Empire in 1869, he was elected a deputy to the national assembly from the Seine, a former department encompassing Paris and its close suburbs.