Alexandru Ene was born on 19 September 1928 in Brăila, Romania and he started playing football at junior level at Olympia București from 1941 to 1947, then he went to play Metalul București at senior level in Divizia B, helping the team promote to Divizia A where he made his debut under coach Augustin Botescu on 22 August 1948 in a 6–1 loss against CFR Timișoara.
[1][4][5][6][8][9][10][11] Afterwards he returned to The Red Dogs where in the 1954 Divizia A season he became the top-scorer of the league with 20 goals and was used all the minutes by coach Angelo Niculescu in the Cupa României final which was lost with 2–0 in front of Metalul Reșița.
[1][4][5][6][8][12] Then in the following season he helped the club win the first Divizia A title in its history, being used by Niculescu in 23 matches in which he scored 14 goals, being the top-scorer of the team.
[1][4][6][14][15] He reached another Cupa României final in 1959, this time winning it as he was used all the minutes by coach Iuliu Baratky in the 4–0 over CSM Baia Mare.
[2] Ene made his last appearance for the national team on 14 September 1958 in a friendly which ended with a 3–2 away loss against East Germany in which he scored one goal.