[3] In 2007, after a brief call-up with the Twins, Casilla became the everyday second baseman after Luis Castillo was traded to the New York Mets.

[4] On May 19, 2008, Casilla hit a three-run homer, his first career MLB home run against Texas Rangers.

In 2009, during the 2009 AL Central tie-breaker game featuring the Twins against the Detroit Tigers, Casilla became the unlikely hero, hitting a game-winning walk-off single to score Carlos Gómez from second base in the bottom of the 12th inning.

[8] On November 30, Casilla signed a one-year, $1.7 million deal with a club option for 2014 to avoid arbitration with Baltimore.

After Brian Roberts went down with an injury three games into the season, Casilla entered a platoon with Ryan Flaherty at second base.

[3] On November 4, Casilla had his $3 million club option declined, and was instead paid the $200,000 buyout, becoming a free agent.

[12] Casilla signed a minor league deal with the Tampa Bay Rays on February 2, 2015.

[15] On June 29, 2015, the Tampa Bay Rays traded Casilla to the Detroit Tigers in exchange for a player to be named later.

[3] On March 9, 2016, Casilla signed a minor league contract with the Toronto Blue Jays organization.

On January 16, 2024, Casilla was announced as the hitting coach for the Long Island Ducks of the Atlantic League of Professional Baseball.