Alezio (Messapic: Alytia; Latin: Aletium) is a town and comune in the province of Lecce in the Apulia region of south-east Italy.

Alezio (despite legend assigning its foundation to a king of Crete) was a centre of the Messapi, who would call it Alytia like their former capital in Acarnania.

Around the year 1000, Alezio was destroyed by the Saracens, its inhabitants moving to the Gallipoli island.

Within Alezio is a 60-hectare (150-acre) region that produces red and rose DOC wines that are a blend with up to 20% Negroamaro, plus Sangiovese, Malvasia and Montepulciano.

[3] Alezio is served by a railway station of the Ferrovie Sud-Est, which also holds several bus services in the area.