The first government of Alfonso Fernández Mañueco was formed on 17 July 2019, following the latter's election as President of the Junta of Castile and León by the Cortes of Castile and León on 9 July and his swearing-in on 12 July, as a result of the People's Party (PP) and Citizens (Cs) being able to muster a majority of seats in the Cortes following the 2019 Castilian-Leonese regional election.

Until 2021, the cabinet comprised members of the PP and Cs, to become the first coalition government to be formed in the region.

On 20 December 2021, regional president Mañueco expelled all Cs members from the cabinet under a pretext to call a snap regional election.

[1] It was automatically dismissed on 14 February 2022 as a consequence of the 2022 regional election, but will remain in acting capacity until the next government is sworn in.

[8] Alfonso Fernández Mañueco's first government was organised into several superior and governing units, whose number, powers and hierarchical structure varied depending on the ministerial department.