While mostly famous as the solitary Italian madrigalist working in England, and the one mainly responsible for the growth of the madrigal there, he also composed much sacred music.
Throughout his life he made periodic trips to Italy, not without controversy, for evidently neither the Pope nor the Inquisition fully approved of his spending time in England, which was in the late 16th century actively at war with Roman Catholic countries.
Many have said that he was a secret service agent for Elizabeth, working during a time when such intelligence was desperately needed; however, little more than circumstantial evidence has ever been produced on this allegation.
Most of his madrigals were for five or six voices, were light in style, and largely ignored the progressive developments in Italy such as expressive chromaticism and word-painting.
In addition to the madrigals, Ferrabosco wrote sacred music, including motets, lamentations, and several anthems, all in a cappella vocal style.