Born in Bologna, Domenico was one of four sons of Annibale Ferrabosco, members of a distinguished Bolognese family whose genealogical records date back to the middle of the 15th century.
He was a singer at the cathedral of San Petronio, and by 1540 had established a high enough reputation for his various musical activities that the city officials gave him a lifetime stipend to oversee the palace musicians.
Ferrabosco probably did not go back to Bologna after this, but instead went to Paris with his family, where three of his sons – including Alfonso, who was to become a renowned musician in England much later – enjoyed the patronage of the influential Cardinal of Lorraine, Charles de Guise.
[4] By 1570 Ferrabosco was back in Bologna taking care of his estate, arranging for succession of his Senate-granted scribal position to his eldest son, and making out his will, which was dated 1573.
Yet his music appears alongside Rore's, for example in that composer's second madrigal book for five voices (1544) which includes Ferrabosco's setting of the sonnet Più d'alto Pin ch'in mezz'un'orto sia.
[6] As texts for his madrigals, Ferrabosco preferred love lyrics, including works by Petrarch, Pietro Bembo, Ludovico Ariosto, and others; many of the poets remain anonymous.