Alfonso Franco (1466–1524), was an Italian painter from Messina, Sicily, active during the Italian Renaissance.
He was a pupil of Jacobello da Antonello, son of Antonello Da Messina.
He painted a Deposition for the church of San Francesco di Paola in Messina; and a Dispute of Jesus at the Temple for the church of Sant'Agostino.
He died of the plague in 1524.
This article about an Italian painter born in the 15th century is a stub.