He received a nomination for the Primetime Emmy Award for Outstanding Directing For a Miniseries or Movie for American Horror Story: Coven.

In high school, Rejon would "borrow a friend's camera" and "make shorts in lieu of presenting a report in front of the class.

[4] Gomez-Rejon then gained extensive experience as a second unit director, including such films as Babel, Julie & Julia and Argo.

[5] He cast most of the "unknown parts" in Babel, which earned him a chance to assist Ryan Murphy in finding authentic Balinese personnel for Eat Pray Love.

[11] On December 1, 2011, Gomez-Rejon directed about six surprise singing and dancing mall performances of "Home for the Holidays" by Carly Foulkes and 100 Chicago-area women in magenta dresses.

[12][13] The full video that has been posted on YouTube has a run time of 3:48 and it will be presented in a 60-second national television commercial starting on December 12.

[33] On November 13, 2015, Gomez-Rejon is set to direct Let It Bleed, a crime thriller based on his early life in Laredo, Texas.

[36] On April 12, 2018, Gomez-Rejon is set to direct Limelight, the biopic of Peter Gatien the owner of the nightclub of the same name for Amazon Studios.

[38] Alfonso, who is of Mexican American descent, was born and raised in Laredo, Texas on the US/Mexico border where he attended St. Augustine High School.