Alfredo de los Santos (born October 17, 1969) is a Dominican-American Para-cyclist.

He represented the United States in the 2016 and 2020 Summer Paralympics.

In the latter, he won a bronze medal in the mixed team relay H1–5.

[2] De los Santos has a bachelor's degree in graphic design from City College of New York and served in the United States Army.

He was injured during a grenade attack in Afghanistan in 2009, resulting in traumatic brain injury and his right leg being amputated above the knee.