Ali-Akbar Zargham (Persian: علی اکبر ضرغام; born 24 February 1911; died 22 December 1976) was a military officer and held several cabinet posts in the cabinets of Manouchehr Eghbal and Jafar Sharif-Emami.

He graduated from the Military Academy in 1934, and eventually finished his military studies at the War University (now known as the National Defense University) in 1940.

In 1951, Zargham was assigned to the military governor's office and was appointed as the director-general of the Department of Sugar the following year.

On 4 April 1957, he was chosen as the customs minister under Eghbal's cabinet.

On 22 December 1976, Ali-Akbar Zargham died from a heart attack in his home in Tehran at the age of 65.