Mir Ali Ahmed Khan Talpur (died 5 April 1987) was a Pakistani politician who served as the 15th defence minister of Pakistan from 1978 to 1985 in the government of general Zia-ul-Haq.

When Pakistan was formed as a sovereign state in 1947, he was imprisoned for six months under court-martial law.

[2] He was among the five cabinet ministers to support Zia's campaign for Islamic law enforcement in Pakistan.

Mir's body was brought back to country and buried in his ancestral graveyard "Ganju Takkar" in Hyderabad, Sindh on 8 April 1987.

President of the country, Provincial Governors high military and senior civil officials and Political and social figures participated in Mir Sahib's funeral prayer, the prayer was led by Moulana Muhammad Ali Rezvi, ex:MNA.