He also served as the President of PTI's Sindh chapter He remained a member of the National Assembly of Pakistan from August 2018 to January 2023.

He received 2,941 votes and lost the seat to Nasrullah Khan, a candidate of the MMA.

He received 7,589 votes from NA-208 (Jacobabad) and lost the seat to Aijaz Hussain Jakhrani.

[4][2] In December 2015, he announced that he would resign as president of PTI's Karachi chapter in the aftermath of party's poor performance in local government elections.

[9][10] Ali Zaidi was appointed as PTI's Sindh Chapter president by Imran Khan on 25 December 2021.