[1] In 1868, she married William Sproston Caine, a prominent iron merchant and active temperance leader, and afterward Member of Parliament.

[1] A painting by Edwin Long of Mrs. Caine and her eldest daughter hung in the dining room of the family home in Clapham Common.

[6] She was affiliated with a number of temperance organizations, becoming president of the Women's Total Abstinence Union, and also of the Auxiliary of the Free Church Council.

Caine was also an active member of the Committee of the Young Abstainers' Union,[4] besides holding membership and official relations in various other subordinate organizations; for example, Caine served as president of Deaconesses' National Total Abstinence League, federated to the Women's Total Abstinence Union.

[7] One of her most responsible positions was that of treasurer of the Anglo-Indian Temperance Association, of which her husband was the founder; and she assumed that additional office after his death in 1903.