She was the founding secretary of the National Association of Negro Musicians (NANM), and was head of the instrumental music program at Tuskegee Institute beginning in 1916; she also taught at Fisk University.
[2] In 1910, Simmons played the first-night concert to open the Morton Theatre in Athens, Georgia.
[3][14] She accompanied singer Cleota Collins and violinists Clarence Cameron White and H. Harrison Ferrell in concerts at Tuskegee.
[24][25] In her last years, she was director of Club Caroline, a residence for Black working women in New York City.
[26] Alice Carter Simmons died from complications after surgery in 1943, aged 60 years, at a hospital in New York City.