In 1354, at the age of four, Alice was betrothed to her father's ward Edmund Mortimer who would in 1360 become the 3rd Earl of March.

Lord Holland was appointed captain of the English forces in Aquitaine in 1366, and in 1375, he was made a Knight of the Garter.

In 1399, King Richard was deposed, and the throne was usurped by Henry IV, the son-in-law of her elder sister, Joan.

In January 1400, Alice's eldest son Thomas, who had succeeded his father as the 3rd Earl of Kent, was captured at Cirencester and beheaded without a trial by a mob of angry citizens[4] as a consequence of having been one of the chief conspirators in the Epiphany Rising.

Her other notable descendants include the last queen consort of Henry VIII, Catherine Parr; Richard Neville, 16th Earl of Warwick—known in history as Warwick the Kingmaker; Cecily Bonville; John Tiptoft, 1st Earl of Worcester and the scandalous Anne Bourchier, 7th Baroness Bourchier.