Alice in Chains regrouped in 2005, with DuVall joining in 2006 as rhythm guitarist and sharing lead vocal duties; the band has since released three more albums: Black Gives Way to Blue (2009), The Devil Put Dinosaurs Here (2013) and Rainier Fog (2018).

Before the formation of Alice in Chains, Layne Staley, a drummer at the time,[13][14] landed his first gig as a vocalist when he auditioned to sing for a local glam metal band known as Sleze after receiving some encouragement from his stepbrother Ken Elmer.

[20] Two weeks after the band's formation, they were playing a gig at Washington State University, trying to fill out a 40-minute set with a couple of original songs along with Hanoi Rocks and David Bowie covers.

Curtis and Silver passed the demo on to Columbia Records' A&R representative Nick Terzo, who set up an appointment with label president Don Ienner.

[41] In early 1991, Alice in Chains landed the opening slot for the Clash of the Titans tour with Anthrax, Megadeth, and Slayer, exposing the band to a wide metal audience but receiving mainly poor reception.

[44] The EP also features Mark Arm of Mudhoney and Chris Cornell of Soundgarden, who shared vocals with Staley and Cantrell on the song "Right Turn", credited to "Alice Mudgarden" in the liner notes.

"[22] While Alice in Chains was inactive during 1995, Staley joined the "grunge supergroup" Mad Season, which also featured Pearl Jam guitarist Mike McCready, bassist John Baker Saunders from The Walkabouts, and Screaming Trees drummer Barrett Martin.

[52] In April 1995, Alice in Chains entered Bad Animals Studio in Seattle with producer Toby Wright, who had previously worked with Corrosion of Conformity and Slayer.

[80] Alice in Chains performed four shows supporting the reunited original Kiss lineup on their 1996–97 Alive/Worldwide Tour, including the final live appearance of Layne Staley on July 3, 1996, in Kansas City, Missouri.

[83] Although Alice in Chains never officially disbanded, Staley became a recluse, rarely leaving his Seattle condominium following the death of his ex-fiancée Demri Parrott on October 29, 1996.

"[22] Unable to continue with new Alice in Chains material, Cantrell released his first solo album, Boggy Depot, in 1998, also featuring Sean Kinney and Mike Inez.

[39] Originally intended for Cantrell's second solo album,[87] the songs were reworked by Alice in Chains and were released in the fall of 1999 on a box set, Music Bank.

[90] In June 2001, Mike Inez joined Zakk Wylde's Black Label Society for the remaining dates of Ozzfest, following the departure of bassist Steve Gibb for medical reasons.

[104] On February 18, 2005, Jerry Cantrell, Mike Inez, and Sean Kinney reunited to perform for the first time in nine years at K-Rock Tsunami Continued Care Relief Concert in Seattle.

[105] The band featured Damageplan vocalist Pat Lachman, as well as other special guests including Maynard James Keenan of Tool and Ann Wilson of Heart.

[107] On March 10, 2006, the surviving members performed at VH1's Decades Rock Live concert, honoring fellow Seattle musicians Ann and Nancy Wilson of Heart.

[118] Between 2001 and 2002, Comes with the Fall was both the opening act on Cantrell's tour for his second solo album, Degradation Trip, and also his backing band,[117][119] with DuVall singing Staley's parts at the concerts.

On June 30, 2009, the song "A Looking in View" was made available for purchase via iTunes and Amazon,[150] and for a limited time it was available as a free download through the official Alice in Chains website in early July.

[193] The video was released on April 3, 2013, and also features cameos by Ann and Nancy Wilson from Heart, Mike McCready from Pearl Jam, Kim Thayil from Soundgarden, Duff McKagan from Guns N' Roses, Brent Hinds and Bill Kelliher from Mastodon, and Lars Ulrich and Robert Trujillo from Metallica.

"[221] At the press room of the Rock and Roll Hall of Fame Induction Ceremony on April 14, 2018, Cantrell revealed that Alice in Chains had just signed with BMG, and that they had finished mixing their new album.

[244] In June 2018, William DuVall said in an interview with Swedish website Rocksverige that the music video for "The One You Know" is the first chapter of what the band is hoping will be visuals for all ten songs from the album Rainier Fog, and in addition to that, will be a companion piece to the film that director Adam Mason was shooting.

[245] On August 20, 2018, the baseball team Seattle Mariners hosted a special "Alice in Chains Night" at the Safeco Field in Seattle to promote Rainier Fog, with the team offering the fans a package that included a Safeco Field terrace club ticket, access to a pre-game listening party of the album, an Alice in Chains T-shirt and a Rainier Fog CD.

[247] To mark the launch of the album, on August 21, 2018, Alice in Chains performed an acoustic set at the top of Seattle's Space Needle and debuted the song "Fly".

[262] The official music video for "Rainier Fog" was released on YouTube on May 15, 2019, and was co-directed by Alice in Chains and Peter Darley Miller, who also directed the band's 2013 mockumentary, AIC 23.

[264] The benefit concert featured tribute performances from artists such as Ann Wilson, Korn, Metallica, Fishbone, Dallas Green, Billy Corgan, Tad Doyle, members of Soundgarden and Pearl Jam, among others.

In an April 2022 interview, vocalist William DuVall revealed that he was "sure" Alice in Chains would begin working on their seventh studio album later in the year: We had a lot of time imposed on us and I think we're going through this period of catching up on things that we had planned for 2020 [and] 2021, and we're all finally getting to do that now.

"[284] In addition, members of Alice in Chains have cited artists including AC/DC,[284][286] Accept,[287][288] Aerosmith,[289] The Beatles,[286] Black Flag,[290] David Bowie,[286] John Coltrane,[289] Miles Davis,[291] Dio,[292] Funkadelic,[293] Hanoi Rocks,[294] Heart,[295] Jimi Hendrix,[296] Iron Maiden,[289] Jethro Tull,[297]King's X,[298] Kiss,[286] Led Zeppelin,[286] Lynyrd Skynyrd,[297] Metallica,[289] Steve Miller,[299] Eddie Money,[297] Motörhead,[289] Mudhoney,[14] Ted Nugent,[297] Pink Floyd,[286] the Pixies,[299] Queen,[300] Queensrÿche,[301] the Rolling Stones,[286] Rush,[295] Scorpions,[302] Soundgarden,[303] The Stooges,[304] Television,[304] Thin Lizzy,[289] Robin Trower,[300] U2,[291] UFO,[302] Van Halen,[302][289] the Velvet Underground,[304] Hank Williams,[289] and ZZ Top as influential or inspirational.

[319][320] Billy Corgan revealed that the song "Bleeding The Orchid" from the Smashing Pumpkins' 2007 album Zeitgeist has a bit of an homage to Alice in Chains in the harmonies and was indirectly inspired by the death of Staley.

Other bands that have been influenced by Alice in Chains include 10 Years,[330] Avenged Sevenfold,[331] Breaking Benjamin,[332] Bush,[333] Creed,[334] Dallas Green,[335] Days of the New,[334] Disturbed,[336] Hoobastank,[337] Incubus,[338] Korn,[339] Manic Street Preachers,[340] Mudvayne,[341] Nickelback,[334] A Pale Horse Named Death,[342] Puddle of Mudd,[334] Queens of the Stone Age,[343] Rains,[344] Seether,[345][346] Skunk Anansie,[347] Smile Empty Soul,[348] Stone Sour,[349] Tantric,[52] Taproot,[350] and Theory of a Deadman.

Their songs were covered by various metal bands such as In Flames,[353] Opeth,[354] Dream Theater,[355] Secrets of the Moon,[356] Suicide Silence,[357] 36 Crazyfists,[358] Cane Hill,[359] Ektomorf,[360] Dritt Skitt,[361] Grave[362] and Thou, who described their 2018 EP Rhea Sylvia as "a melodic grunge, Alice in Chains homage.