As Hugh was only five at the time, Alice became the regent of Burgundy during his minority, serving with the title "Ducissa mater ducis Bourgogne".

As regent, Alice worked to secure the inheritance of her son, and received the vassals' oath of loyalty in his place.

In 1225, she managed to prevent a conflict with the dauphin of Viennois, from whom she acquired Beaune and Chalon by way of purchase as a means of ensuring peace.

In 1228, her son was declared of legal majority, and Alice resigned her regency, leaving court in order to retire to her dower lands.

However, in 1231, she acted as her son's representative in successfully resolving the conflict between the vicomte de Dijon and the abbey of Citeaux.