[24] Key social projects include Loneliness in the City (1999-2000), which travelled to six different international cities and invited artists, architects, designers, and the general public to a portable pavilion where the aim of inventing strategies against the epidemic of urban loneliness was explored, Welcome to Guantanamo Museum (2008), a multifaceted project involving drawings, scale models, and floor plans of a proposed memorial for the infamous U.S. detention camp, and Billboardhouse (2000-2009), an open-side cube made of three billboards that costs almost nothing to make and serves as a shelter for homeless individuals.

In 2003 Framis released her project anti_dog, a collection of designs made with a special fabric, Twaron, that is fire-, bullet-, and dog bite-proof.

This highlighted the explosion of the garment export industry in modern China, while also questioning how the associations of nationhood could both empower and burden the wearer.

Framis uses garments to explore the borders of that which is private and that which is public, and wishes to focus attention on the issue of women's control over their own bodies.

While the aesthetics of the dresses resemble that of lingerie, a material usually associated with the private realm, with moments of intimacy inside the home environment, they are at the same time used actively in performance demonstrations, where the viewer is confronted with the women's message and asked to reflect upon this.

[26] The belief that humans can achieve a more fulfilling future is a key component of Framis's work, and is shown through projects that deal with the delicate act of wishing.

This interactive piece was later shown by Jan Hoet and Nicolas Bourriaud, the curator recognized as coining the term "relational aesthetics."

Framis's sculpture Cartas al Cielo (2012), a stainless steel sphere 5 feet in diameter, was created to act as a postbox where one can send letters to the members of our lives who are no longer physically with us.

[36] Framis's notable solo exhibitions include at presentations at Sala Alcalá 31, Madrid (2018),[37] Stedelijk Museum Amsterdam (2017),[38] MUSAC, Castilla y Léon (2014),[39] Museum voor Moderne Kunst Arnhem (2013),[40] La Frac Haute-Normandie, Rouen (2012),[41] Ullens Center for Contemporary Art, Beijing (2010), Centre Pompidou, Paris (2010), El Museo del Barrio, New York (2004)[42] and Palais de Tokyo, Paris (2002),[43] among others.

[45] Framis is represented by Barbara Gross Galerie in Munich, Germany,[46] Galeria Juana de Aizpuru in Madrid, Spain[47] and Upstream Gallery in Amsterdam, the Netherlands.