The first Aliens versus Predator centers on Ryushi, a recently colonized planet, and Machiko Noguchi, the Chigusa Corporation's administrator there.

The settlers on Ryushi raise cattle-like quadrupedal ungulates called rhynth for export to other solar systems, and at the time of the story are in the process of assembling a shipment of the native livestock.

On board the Predator ship, the prey are prepared: an Alien queen lays eggs for delivery to Ryushi.

Meanwhile, the infected Rhynth have been loaded aboard a cargo transporter and, with a queen among their number, an Alien colony quickly takes hold.

Broken Tusk, now recovered due to the intervention of a human doctor, sides with Machiko, and together with the cargo ship's crew they arrange for the transporter's massive orbiter to crash into Ryushi and destroy the colony and the Aliens.

In the ensuing fight, Broken Tusk is mortally wounded, but, admiring the courage of his human comrade, "bloods" Machiko with the mark of his clan.