In 1916 Guggenheim opened a fashion house in Zürich, called the Salon des Modes.

She met a Russian student and communist named Mischa Berson with whom she travelled to the Soviet Union at the beginning of 1919.

[2] Following the failure of her relationship with Berson, Guggenheim returned to Switzerland, re-opened her salon and joined the Swiss Communist Party.

In 1954 Guggenheim received the Swiss Federation of Jewish Communities Art Prize.

Alis Guggenheim died in 1958, following a brief illness, and was buried in the Jewish cemetery in Lengnau.