She made her debut at age 13 with the Cleveland Orchestra playing Tchaikovsky's Variations on a Rococo Theme.

In 2000–01, she won an Avery Fisher Career Grant and was selected to play in the ECHO "Rising Stars" program and Chamber Music Society II, the young artists' program of the Chamber Music Society of Lincoln Center.

[7] A champion of contemporary music, Weilerstein has worked extensively with composers Osvaldo Golijov, Lera Auerbach and Joseph Hallman.

[8] She performed the New York premiere of Golijov's Cello Concerto "Azul" at Lincoln Center's Mostly Mozart Festival, the world premiere of Auerbach's 24 Preludes for Cello and Piano at the Caramoor International Music Festival, Auerbach's transcription of Shostakovich Op.

[9] In May 2016, she premièred Outscape, Pascal Dusapin's second cello concerto, with the Chicago Symphony Orchestra, to positive critical reception.