On 16 August 2013, after retaining a starting spot under Claudinei Oliveira, Alison renewed his link with Santos until December 2017.

[10] On 20 January 2017, Alison was loaned to Red Bull Brasil until the end of the 2017 Campeonato Paulista, in order to regain match fitness.

[11] Upon returning, he started to feature regularly with the first team under Levir Culpi, becoming a starter after the departure of Thiago Maia to Lille OSC.

[19] He returned to action on 26 April, replacing Rodrigo Fernández in a 1–0 home win over Botafogo-SP, for the year's Copa do Brasil.

[20] Alison became a first-choice in late May 2023, after Fernández's poor form, but suffered another knee injury in June, being sidelined for the remainder of the year.

Earlier in that year, he was also called up to the under-23s for a training period, but Santos deemed him unavailable due to his commitments at the club.