Born in Rio Pomba, Minas Gerais, Alisson joined Cruzeiro's youth setup in 2007, aged 13.

Alisson made his first team – and Série A – debut on 18 November 2012, coming on as a second-half substitute for Walter Montillo in a 2–0 away win over Fluminense.

[2] He featured in a further two Campeonato Mineiro matches for the club before being loaned to Vasco da Gama on 18 April 2013, as a part of the deal which saw Dedé move to the opposite direction permanently.

[3] While at the Cruzmaltino, Alisson scored his first professional goal, netting the opener in a 2–0 home win over Atlético Mineiro on 5 June 2013.

Alisson scored his first goal for Tricolor on 7 February 2018, netting the equalizer in a 2–1 home win over Brasil de Pelotas.