After his father dedicated his life to eliminating Spider-Man and died as a result, Alistair inherited his Spider-Slayer legacy and developed a hatred for the web-slinger.
He turned to a life of crime to exact revenge on Spider-Man, and created a new generation of Spider-Slayers to kill him, but this only resulted in Alistair getting paralyzed from the waist down.
Later, he encased his body in a bioorganic carapace that allowed him to walk again, in addition to giving him superpowers, and adopted the alias of the Ultimate Spider-Slayer.
Spencer failed to kill Spider-Man—and ended up dying as a result of prolonged exposure to the radioactive samples involved.
Alistair encased himself in an organic carapace that not only served as a full body armour, but also increased his strength and gave him the ability to walk again by interconnecting with his spine.
[4] During Scarlet Spider's brief stint as sole web-slinger in town, Smythe (carapaced as the Ultimate Spider-Slayer) started a war utilizing a new set of slayers he intended to sell on the black market.
These Cyber-Slayers, which could be controlled remotely by turning one's thoughts into the slayers' actions, were initially targeted at Lady Octopus and her crew.
[6] Smythe, no longer in his carapace but with his ability to walk restored by his earlier use of it, found his way outside prison and sought revenge on both Spider-Man and J. Jonah Jameson for the death of his father.
While attached to Spider-Man's head, the miniature spider-slayer psionically connected to Spidey's mind, copied thoughts of his loved ones, and broadcast that information to all the other mini-slayers.
Spider-Man eventually shut down all the spider-slayers at the same time, but it was Jameson who beat Smythe to the verge of death with a baseball bat for threatening his family.
[7] During the "Big Time" storyline, Smythe returns with a new metallic body armor and is hunting down all of J. Jonah Jameson's friends and family.
[13] During the "Spider-Island" storyline, J. Jonah Jameson brings Alistair Smythe from Ryker's Island to demand his help in resolving the spider-flu plague transforming ordinary citizens into Homo Arachnis.
Smythe takes the upper hand until he is narrowly shot down by Mayor Jameson disguised as a Raft guard.
Smythe manages to reach the Raft's generators, destroying them to shut down the power in the entire island, allowing the Lizard to escape.
Smythe warns Superior Spider-Man that just like he does with his Spider-Bots, he can see through his Mini-Slayers catching up on Mayor Jameson and the trapped civilians sending their locations to the group.
While wearing this armor, Alistair was granted enhanced durability, speed, agility, and reflexes, as well as clinging to solid surfaces.
[28] This version is a supervisor at Oscorp who orders Max Dillon to check an electrical fault, which leads to the latter's transformation into Electro.
Additionally, a viral marketing campaign for the film featured a Daily Bugle article that mentions Alistair having replaced his father as the head of Oscorp's engineering division.