She first worked in Rome as Claudia Cardinale's assistant on films including Federico Fellini's 8 ½, Luchino Visconti's The Leopard and Blake Edwards’ The Pink Panther.
Films produced and/or released during Pfeiffer's presidency include Choose Me, El Norte, Koyaanisqatsi, Stop Making Sense, Insignificance, The Hit, A Private Function and Kiss of the Spider Woman.
Between 1993 and 1999, following the death of Jon Bradshaw, Pfeiffer and her daughter Shannon moved to Jamaica where, with her brother Bill, she owned the master franchise for TCBY for the island.
In 2013 she executive produced Cory Van Dyke's Far Marfa, in 2015 Hector Galan's award-winning PBS documentary Children of Giant, and in 2018/2019 Keith Maitland's Dear Mr. Brody, which was theatrically released and broadcast on Discovery in 2022.
In 2019 she produced a one-woman play, Ilsa by William Benton, starring Kate O'Toole and directed by Richard Maxwell of New York City Players.
She is executive producing Robert Irwin: A Desert of Pure Feeling, a documentary on the famed light and space artist directed by Jennifer Lane to be released late 2022/2023.