Alkyl-lysophospholipids

Alky-lysophospholipids (ALPs) are synthetic analogs of lysophosphatidylcholines (LPCs), also called lysolecithins.

They are synthesized by replacing the acyl-group within the LPC with an alkyl group.

[1][2] ALPs are being studied for their potential antineoplastic (anti-cancer)[1] and immune-modulating effects.

[2] Their anti-tumor effects are due to modulation of intracellular signalling pathways, inducing apoptosis.

[2] Several examples including edelfosine, miltefosine, and perifosine are under development as drugs against cancer and other diseases.

Chemical structure of edelfosine , an alkyl-lysophospholipid being studied for its potential use as a pharmaceutical drug