All About Chemistry is the third studio album by American rock band Semisonic, released on March 13, 2001, through MCA Records.

With this release, the band failed, at least in America, to capitalize on the momentum it had generated with the song "Closing Time" from their previous album, Feeling Strangely Fine.

By 2002, the album had sold 58,000 copies,[10] and its poor sales partially led to the band going on an unofficial hiatus.

The song "One True Love" was co-written by the band's singer/guitarist, Dan Wilson and music legend Carole King.

The title track was included on the album "Nolee Mix" which was released to promote the My Scene dolls.