The Stooges operate a local drugstore whose landlord, the cantankerous Amos Flint, informs them their lease is about to expire.

However, their bickering takes a poignant turn when they encounter Flint's elderly wife, Cerina, who is subjected to his harsh treatment.

Moved by Cerina's plight, the Stooges offer her shelter in their store's spare room, igniting a chain of events driven by Shemp's inventive idea to create a "Fountain of Youth" serum.

In a surprising turn, Amos rescinds his eviction threat and even transfers the store's deed to the Stooges in exchange for a dose of the serum.

Although Stooge critic Jon Solomon contends that the remake has a better story flow than the original, that sentiment is not shared by fans.