The current building, the construction of which was completed in 1888, is at least the third version of the church, which dates back to at least the early 13th century.

[6][7] The firm chosen to execute Gambier-Parry's Gothic design was Mackenzie & Sons of Newark-on-Trent, Nottinghamshire.

[4] The firm selected to produce the stained-glass windows was that of Clement Heaton, James Butler, and Robert T. Bayne, founded in 1952.

[8][9] The site of the church, off Gainsborough Road, was that occupied by Parliamentary troops during their attacks on Newark-on-Trent at the time of the English Civil War of the mid 17th century.

However, following the passage of the Act of Uniformity in 1559, decades earlier, a report made in August 1559 found that the chancel was already roofless.

[12] As the second building was razed in 1886, excavation revealed the base for a cannon, gunpowder, and hundreds of skeletons.

The consecration was postponed from 7 June 1888 as the Bishop of Southwell had taken ill.[4][14] The church was Grade II listed on 15 October 1984 by English Heritage.

[15][16] In 1996, Anthony Keeble Shaw was appointed priest-in-charge of All Saints' Church, Winthorpe.

The lower portion of the tower features the entrance to the building, as well as a porch with a staircase that extends up to the belfry.

[10] An apsidal baptistry which projects from the west side of the nave has three lancet windows, over which is a band course.

The south wall of the nave has three double lancet windows, each of which is surmounted by a cinquefoil and band course.

The interior of the building contains a ceiling boss, door lock with key, royal arms, and some monuments from the previous church.

Other tablets dedicated to the memory of members of the Handley family line the walls of the vestry.