Born in Neuilly-sur-Seine, France, Nyom only played amateur football in the country, competing in the reserves championship with AS Nancy-Lorraine and appearing for AC Arles-Avignon in the Championnat National.

In the summer of 2009 he was signed by Udinese Calcio from Italy,[4] and was immediately loaned to Granada CF in Spain as part of the partnership agreement between both clubs.

Nyom quickly became an undisputed first-choice with the Andalusia side, helping them promote from Segunda División B to La Liga in just two seasons.

[15] On 24 July 2019, after his loan spell with Lega ended, Nyom joined Getafe on a two-year contract with an option for another[16][17] – West Bromwich continued to complain to FIFA asking for £2.7million compensation.

[22] He was selected by manager Volker Finke for his 2014 FIFA World Cup squad,[23] and made his debut in the tournament on 23 June against Brazil with the "Indomitable Lions" already eliminated from the knockout phase after two losses.