Moukandjo began his career in hometown's Kadji Sports Academy, joining the club's youth setup in 1998, aged 10.

[7] On 8 April 2017, he scored two of Lorient's goals and provided an assist for Sylvain Marveaux in their 4–1 league away win over Lyon.

[8] On 13 July 2017, Moukandjo moved to the Chinese Super League side Jiangsu Suning on a two-year deal.

[20] Moukandjo was selected in Cameroon's squad for the 2014 FIFA World Cup and started in all three group matches, against Mexico, Croatia and Brazil respectively.

[22] Two years later, he was named Man of the Match in the final as Cameroon won the Africa Cup of Nations for the fifth time.