Incumbent Democratic Senator Jack Reed was challenged by Republican nominee Allen Waters.

Waters was later disavowed by the state Republican Party after charges of domestic assault in 2019 became public.

[1] Reed easily won a fifth term in office with 66.5% of the vote and a 33.1% margin.

Despite his clear landslide victory, this was actually his worst Senate re-election performance, and the first time since his initial election to the U.S. Senate in 1996 in which he failed to receive at least 70% of the vote.

Nevertheless, he outperformed Democratic presidential nominee Joe Biden by 7.2% in the concurrent presidential election, the largest overperformance by any Democratic Senate candidate in 2020.