The seminary was originally founded in 1899 in Wuzhou, Guangxi, under the name Alliance Bible College.

[2] In 1949, the seminary was moved to Cheung Chau, Hong Kong by Dr. William C. Newbern after the Communist takeover of mainland China.

[3] In 1902, the Seminary established the Alliance Women's College, the first institute of its kind in the Guangxi province.

[4] Following the establishment of the People's Republic of China in 1949,[4] Alliance Bible College relocated to Cheung Chau, Hong Kong, where it resumed operations in 1950.

[4] The founding of the Graduate School led to an increase in academic theological and cultural engagement within the Seminary, beginning with the establishment of the Christianity and Chinese Culture Research Centre in the same year, and the inaugural publication of a Biblical studies journal, Jian Dao: A Journal of Bible and Theology, in 1994.

[4] This expansion continued with the purchase of the City Campus site at Wan Chai in 2005, its opening in the following year.

[10] Alliance Bible Seminary awards multiple prizes and scholarships to its students, with funds drawn from a number of sponsoring bodies.

These bodies include: the Chinese Christian Church, Aize Foundation, Mr Huang Bingqian, Xuanhaohui Xinghua Hall, COCM Christian Overseas Chinese Missionary Society, Gospel Masters Association, Global Bible Society, the Tiandao book Building, the Life and Marriage Enlightenment Training Co., Hong Kong and Kowloon Pei Ling Research and Development Co., Missionary Church Hebron, Missionary Association Hong Kong, Missionary Church North Point, and Jin Balun Presbyterian Church Chau Chau.