[4] Pankiw began her career with Partizan Midi-Minuit, directing music videos for artists such as Kira Isabella, Ralph, Muna, Janelle Monáe and Arkells,[3] as well as making short films.
Beginning in 2017 she directed the comedy web series Terrific Women for CBC Gem,[5] as well as becoming a story editor on the television sitcom Schitt's Creek.
[3] She subsequently directed the entire first season of Mae Martin's semi-autobiographical comedy series Feel Good,[6] as well as episodes of Shrill and The Great.
[7] In 2022, she was announced as co-creator with Dan Levy of Standing By, an animated comedy series about a group of disgruntled guardian angels, for Hulu.
[4] She also directed "Joan Is Awful", a 2023 episode of the anthology series Black Mirror which starred Annie Murphy and Salma Hayek.