He received international prominence and critical acclaim for starring as David Rose in the CBC sitcom Schitt's Creek (2015–2020), which he co-created and co-starred in with his father, Eugene Levy.

[4] Levy has since played a supporting role in the romantic comedy film Happiest Season (2020), and starred in, written and directed the drama Good Grief (2023).

He also co-hosted the MTV Movie Awards Red Carpet, the X-Factor pre-show, and national coverage of the Vancouver 2010 Winter Olympics for CTV.

[20] Levy has spoken publicly about his character's portrayal of pansexuality, saying, "I think in certain parts of America, David's sexual ambiguity was a big question mark.

[25] In July 2017, it was announced that Levy would host The Great Canadian Baking Show with Julia Chan, which had its premiere on November 1 on CBC.

[26] On October 30, John Doyle of The Globe and Mail criticized the show's first episode in a review, including a critique of Levy's "feyness" while performing as host.

[28][29] The Globe's public editor Sylvia Stead published a statement on November 9 explaining that "Mr. Doyle was not aware that Mr. Levy was gay and he used the term to mean preciousness".

[33] In June 2019, to mark the 50th anniversary of the Stonewall riots that sparked the start of the modern LGBTQ rights movement, Queerty named him one of the Pride50 "trailblazing individuals who actively ensure society remains moving towards equality, acceptance and dignity for all queer people".

They did many of the ordinary host activities including interviewing fellow Schitt's Creek cast members Catherine O'Hara and Annie Murphy.

[39][40][41] In August 2020, Levy enrolled in and began to promote the 12-week self-paced Massive Open Online Course (MOOC), "Indigenous Canada", hosted by Dr. Tracy Bear (Montreal Lake First Nation) and Dr. Paul Gareau (Métis and French Canadian) of the University of Alberta.

[45] In September 2020, Levy starred alongside Bette Midler, Kaitlyn Dever, Sarah Paulson, and Issa Rae in the HBO television film Coastal Elites.

[51] The film stars Levy, Ruth Negga, Luke Evans, Himesh Patel, Celia Imrie, David Bradley, and Arnaud Valois.