Although her initial success came at the Metropolitan Opera in New York City, Gluck later performed widely in America and became an early recording artist.

Although various sources claim that her recording of "Carry Me Back to Old Virginny" for the Victor Talking Machine Co. was the first celebrity recording by a classical musician to sell one million copies, Victor ledgers do not support the claim—nor did Gluck ever make such a claim herself.

Although by background an assimilated and nonpracticing Jew who continued to consider herself ethnically Jewish, she found herself attracted, along with her husband Efrem, to Anglican Christianity, and they regularly attended the Episcopal Church in New Hartford.

[5][6][7][8] Gluck recorded several Christian hymns in duet with Louise Homer, among them "Rock of Ages",[9] "Whispering Hope",[10] "One Sweetly Solemn Thought",[11] and "Jesus, Lover of My Soul".

[12] After a long illness, she was taken to the Rockefeller Institute Hospital in Manhattan, New York City, but died from liver failure several days later, on October 27, 1938, at the age of 54.