In 2019, Littles received the Elizabeth Blackwell Award from the American Medical Women's Association.
Littles was born in Quincy, Florida as the youngest of 12 children in a family of rural farm workers.
[1][2] She is the first in her family to attend college, graduating with a Doctor of Medicine (MD) in 1986 from the University of Florida.
[6] Littles was heavily involved in the creation and development of the Florida State University (FSU) College of Medicine.
[6][13] In 2014, she was named by Black Health magazine as one of the country's "Top 15 most Influential African American Medical Educators.