Its founder was John Kostopoulos[9] Alpha Bank's Network in Greece has 273 branches and 783 ATMs.

Ioannis F. Kostopoulos, a textile merchant from Sperhogeia in Messinia, founded a commercial shop in 1882 in Kalamata and in 1885 he started to be active in foreign exchange trading.

The dissolution would not take place due to the events of Dekemvriana and after the Treaty of Varkiza the decision of the directors would be revised.

After the difficult 1950s, marked by a recession, the bank began to focus on developing a national network of branches.

In 1984, after the death of his father Spyros, Yannis Kostopoulos assumed the duties of chairman of the board of directors.

[13] In 1989 the bank expanded its activities to London with the establishment of a Representative Office, which shortly afterwards, in 1993, would become a branch.

[25] In 2005 Dimitrios Mantzounis took over as CEO with Yannis Kostopoulos remaining as chairman of the board of directors of the bank.

However, the Board of Directors of Alpha Bank, at its meeting on the 18th of February and after having studied the proposal, decided to reject it on the grounds that the terms were unfavorable for its shareholders.

[28] At the end of August of the same year, the agreement between the boards of directors of Alpha Bank and Eurobank EFG to merge the two organizations was announced, which was however revoked in March 2012.

[33] The Bank redeemed the total amount of the Hellenic Republic's Preference Shares on 17 April 2014.

On 17 July 2015 it sold its Bulgarian branches to Postbank (Bulgaria), the subsidiary of fellow Greek bank Eurobank Ergasias.

[38] As a result of the increase in the bank's share capital, the State's participation, through the Hellenic Financial Stability Fund, was reduced to approximately 11%.